There’s nothing more frustrating to an owner than to leave a draft with a team you think is pretty good, only to realize that the league rules negate your players’ strengths.
Why draft a pass-catching running back if you’re not in a PPR league? What good is it to draft a receiver who perenially leads the league in receptions but never gets into the end zone if you’re not in a PPR league? Why draft a defense before the final few rounds if they only score a few points per week in your league? What good is a receiver who doubles as a kick returner if your league doesn’t score points for return yards?
Study your league rules before the draft and make sure you know what to expect in terms of positional scoring.