Darren Waller

Don't lose your matchup to a tough decision! Get the essential 2025 fantasy football Week 6 start 'em, sit 'em advice for Quarterbacks, Running Backs, Wide Receivers, and Tight Ends to set your most dominant lineup.

Injuries and bye weeks can wreak havoc on your fantasy lineup. Here are a list of players to start and sit for Week 5 of the 2025 NFL season.